Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a superhero, even though he has no powers, training or meaningful reason to do so.

After getting a restraining order from Randal Graves (''Clerks'') for Illegal drug trade outside the Quick Stop, Jay and Silent Bob find out from Brodie Bruce (''Mallrats'') that ''Bluntman and Chronic'', the comic book based on their likenesses, has been adapted into a film in production by Miramax Films. In response, the two visit Holden McNeil (''Chasing Amy''), the co-writer of ''Bluntman and Chronic'' and demand royalties from the film. However, Holden tells Jay and Silent Bob that he sold his part of the creative and publishing rights of the comic over to his former friend Banky Edwards. Upon learning of the film, as well as the negative reaction it has received so far on the internet, the two set out on a quest to Hollywood, to prevent the film from being made and tainting their image, or at the very least receive the money from the royalties owed to them.

Gregorio and Ingrid Cortez are rival spies who fall in love. They retire and have two children, 12-year-old Carmen and 9-year-old Juni. They work for the Organization of Super Spies (OSS) doing desk work. The children have no idea of their parents' previous career. Gregorio and Ingrid are called back into the field when agents go missing. The children are left in the care of their uncle Felix. Gregorio suspects that children's television host Fegan Floop has kidnapped the agents and mutated them into his "Fooglies," creatures on his show.

The teenagers of Disney's most infamous villains return to the Isle of the Lost to recruit a new batch of villainous offspring to join them at Auradon Prep.

Mal struggles with her new celebrity life as the girlfriend of King Ben, putting a spell on her hair making it blonde, and maintaining a princess-like personality that she is uncomfortable with. She admits her issues to her friends Evie, Carlos, and Jay, but they are content with their new lives in Auradon and do not wish to return to the Isle of the Lost. Evie scolds Mal for relying on her mother's spell book to solve her issues. Carlos, wishing to ask Jane to the upcoming Cotillion dance, turns to Mal for help to be honest with her. Mal gives him a sweet that will make him speak the truth, but his dog Dude eats it, magically speaking the truth in English and very frankly as a result.

After making their way through high school (twice), big changes are in store for officers Schmidt and Jenko when they go deep undercover at a local college.